Prostin VR
Prostin VR Brand names, Prostin VR Analogs
Prostin VR Brand Names Mixture
- No information avaliable
Prostin VR Chemical_Formula
C20H34O5
Prostin VR RX_link
http://www.rxlist.com/cgi/generic/alprostadil.htm
Prostin VR fda sheet
Prostin VR msds (material safety sheet)
Prostin VR Synthesis Reference
No information avaliable
Prostin VR Molecular Weight
354.481 g/mol
Prostin VR Melting Point
115 - 116 oC
Prostin VR H2O Solubility
26.7 mg/L
Prostin VR State
Solid
Prostin VR LogP
2.983
Prostin VR Dosage Forms
Liquid; Powder for solution; Solution; Suppository
Prostin VR Indication
For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Prostin VR Pharmacology
Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.
Prostin VR Absorption
The absolute bioavailability of alprostadil has not been determined.
Prostin VR side effects and Toxicity
Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.
Prostin VR Patient Information
Prostin VR Organisms Affected
Humans and other mammals
