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Alprostadil Prostoglandin E1 en es it fr

Alprostadil Prostoglandin E1 Brand names, Alprostadil Prostoglandin E1 Analogs

Alprostadil Prostoglandin E1 Brand Names Mixture

  • No information avaliable

Alprostadil Prostoglandin E1 Chemical_Formula

C20H34O5

Alprostadil Prostoglandin E1 RX_link

http://www.rxlist.com/cgi/generic/alprostadil.htm

Alprostadil Prostoglandin E1 fda sheet

Alprostadil_Prostoglandin_E1 FDA

Alprostadil Prostoglandin E1 msds (material safety sheet)

Alprostadil_Prostoglandin_E1 MSDS

Alprostadil Prostoglandin E1 Synthesis Reference

No information avaliable

Alprostadil Prostoglandin E1 Molecular Weight

354.481 g/mol

Alprostadil Prostoglandin E1 Melting Point

115 - 116 oC

Alprostadil Prostoglandin E1 H2O Solubility

26.7 mg/L

Alprostadil Prostoglandin E1 State

Solid

Alprostadil Prostoglandin E1 LogP

2.983

Alprostadil Prostoglandin E1 Dosage Forms

Liquid; Powder for solution; Solution; Suppository

Alprostadil Prostoglandin E1 Indication

For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Alprostadil Prostoglandin E1 Pharmacology

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.

Alprostadil Prostoglandin E1 Absorption

The absolute bioavailability of alprostadil has not been determined.

Alprostadil Prostoglandin E1 side effects and Toxicity

Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.

Alprostadil Prostoglandin E1 Patient Information

Alprostadil Prostoglandin E1 Organisms Affected

Humans and other mammals