l-Prostaglandin E1
l-Prostaglandin E1 Brand names, l-Prostaglandin E1 Analogs
l-Prostaglandin E1 Brand Names Mixture
- No information avaliable
l-Prostaglandin E1 Chemical_Formula
C20H34O5
l-Prostaglandin E1 RX_link
http://www.rxlist.com/cgi/generic/alprostadil.htm
l-Prostaglandin E1 fda sheet
l-Prostaglandin E1 msds (material safety sheet)
l-Prostaglandin E1 Synthesis Reference
No information avaliable
l-Prostaglandin E1 Molecular Weight
354.481 g/mol
l-Prostaglandin E1 Melting Point
115 - 116 oC
l-Prostaglandin E1 H2O Solubility
26.7 mg/L
l-Prostaglandin E1 State
Solid
l-Prostaglandin E1 LogP
2.983
l-Prostaglandin E1 Dosage Forms
Liquid; Powder for solution; Solution; Suppository
l-Prostaglandin E1 Indication
For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
l-Prostaglandin E1 Pharmacology
Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.
l-Prostaglandin E1 Absorption
The absolute bioavailability of alprostadil has not been determined.
l-Prostaglandin E1 side effects and Toxicity
Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.
l-Prostaglandin E1 Patient Information
l-Prostaglandin E1 Organisms Affected
Humans and other mammals
