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Brand names,
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Analogs
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Brand Names Mixture
- Prinzide (Hydrochlorothiazide + Lisinopril)
- Zestoretic Tab 10/12.5mg (Hydrochlorothiazide + Lisinopril)
- Zestoretic Tab 20/12.5mg (Hydrochlorothiazide + Lisinopril)
- Zestoretic Tab 20/25mg (Hydrochlorothiazide + Lisinopril)
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Chemical_Formula
C21H31N3O5
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RX_link
http://www.rxlist.com/cgi/generic/lisinop.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
405.488 g/mol
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Melting Point
No information avaliable
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H2O Solubility
13 mg/L
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State
Solid
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LogP
-1.22
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Dosage Forms
Tablet
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Indication
For the treatment of hypertension, heart failure and acute myocardial infarction. It may be used alone or in combination with thiazide diuretics
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Pharmacology
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension, congestive heart failure (CHF), postmyocardial infarction, and diabetic nephropathy or retinopathy. Although it is the lysine ester of enalaprilat, the active form of the prodrug enalapril, lisinopril is active unchanged.
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Absorption
Approximately 25%, but widely variable between individuals (6 to 60%)
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side effects and Toxicity
hypotension, LD50= 2000 mg/kg(orally in rat)
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Patient Information
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Organisms Affected
Humans and other mammals