Penicillin G

Penicillin G Brand names, Penicillin G Analogs

Penicillin G Brand Names Mixture

No information avaliable

Penicillin G Chemical_Formula

C₁₆H₁₈N₂O₄S

Penicillin G RX_link

http://www.rxlist.com/cgi/generic3/pengk.htm

Penicillin G fda sheet

Penicillin G msds (material safety sheet)

Penicillin_G MSDS

Penicillin G Synthesis Reference

No information avaliable

Penicillin G Molecular Weight

334.391 g/mol

Penicillin G Melting Point

214-217^oC

Penicillin G H₂O Solubility

Slightly soluble (210 mg/L)

Penicillin G State

Solid

Penicillin G LogP

1.212

Penicillin G Dosage Forms

Powder for solution; Suspension; Tablet

Penicillin G Indication

For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required.

Penicillin G Pharmacology

Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Penicillin G Absorption

Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient.

Penicillin G side effects and Toxicity

Oral LD₅₀ in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams.

Penicillin G Patient Information