Benzopenicillin
Brand names,
Benzopenicillin
Analogs
Benzopenicillin
Brand Names Mixture
Benzopenicillin
Chemical_Formula
C16H18N2O4S
Benzopenicillin
RX_link
http://www.rxlist.com/cgi/generic3/pengk.htm
Benzopenicillin
fda sheet
Benzopenicillin
msds (material safety sheet)
Benzopenicillin
Synthesis Reference
No information avaliable
Benzopenicillin
Molecular Weight
334.391 g/mol
Benzopenicillin
Melting Point
214-217oC
Benzopenicillin
H2O Solubility
Slightly soluble (210 mg/L)
Benzopenicillin
State
Solid
Benzopenicillin
LogP
1.212
Benzopenicillin
Dosage Forms
Powder for solution; Suspension; Tablet
Benzopenicillin
Indication
For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required.
Benzopenicillin
Pharmacology
Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Benzopenicillin
Absorption
Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient.
Benzopenicillin
side effects and Toxicity
Oral LD50 in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams.
Benzopenicillin
Patient Information
No information avaliable
Benzopenicillin
Organisms Affected
Enteric bacteria and other eubacteria