Pencillin G

Pencillin G Brand names, Pencillin G Analogs

Pencillin G Brand Names Mixture

No information avaliable

Pencillin G Chemical_Formula

C₁₆H₁₈N₂O₄S

Pencillin G RX_link

http://www.rxlist.com/cgi/generic3/pengk.htm

Pencillin G fda sheet

Pencillin G msds (material safety sheet)

Pencillin_G MSDS

Pencillin G Synthesis Reference

No information avaliable

Pencillin G Molecular Weight

334.391 g/mol

Pencillin G Melting Point

214-217^oC

Pencillin G H₂O Solubility

Slightly soluble (210 mg/L)

Pencillin G State

Solid

Pencillin G LogP

1.212

Pencillin G Dosage Forms

Powder for solution; Suspension; Tablet

Pencillin G Indication

For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required.

Pencillin G Pharmacology

Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Pencillin G Absorption

Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient.

Pencillin G side effects and Toxicity

Oral LD₅₀ in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams.

Pencillin G Patient Information