Free Penicillin Ii
Brand names,
Free Penicillin Ii
Analogs
Free Penicillin Ii
Brand Names Mixture
Free Penicillin Ii
Chemical_Formula
C16H18N2O4S
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RX_link
http://www.rxlist.com/cgi/generic3/pengk.htm
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fda sheet
Free Penicillin Ii
msds (material safety sheet)
Free Penicillin Ii
Synthesis Reference
No information avaliable
Free Penicillin Ii
Molecular Weight
334.391 g/mol
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Melting Point
214-217oC
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H2O Solubility
Slightly soluble (210 mg/L)
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State
Solid
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LogP
1.212
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Dosage Forms
Powder for solution; Suspension; Tablet
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Indication
For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required.
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Pharmacology
Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
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Absorption
Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient.
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side effects and Toxicity
Oral LD50 in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams.
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Patient Information
No information avaliable
Free Penicillin Ii
Organisms Affected
Enteric bacteria and other eubacteria