Pentids
Brand names,
Pentids
Analogs
Pentids
Brand Names Mixture
Pentids
Chemical_Formula
C16H18N2O4S
Pentids
RX_link
http://www.rxlist.com/cgi/generic3/pengk.htm
Pentids
fda sheet
Pentids
msds (material safety sheet)
Pentids
Synthesis Reference
No information avaliable
Pentids
Molecular Weight
334.391 g/mol
Pentids
Melting Point
214-217oC
Pentids
H2O Solubility
Slightly soluble (210 mg/L)
Pentids
State
Solid
Pentids
LogP
1.212
Pentids
Dosage Forms
Powder for solution; Suspension; Tablet
Pentids
Indication
For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required.
Pentids
Pharmacology
Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Pentids
Absorption
Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient.
Pentids
side effects and Toxicity
Oral LD50 in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams.
Pentids
Patient Information
No information avaliable
Pentids
Organisms Affected
Enteric bacteria and other eubacteria