Oxybutynin
Brand names,
Oxybutynin
Analogs
Oxybutynin
Brand Names Mixture
Oxybutynin
Chemical_Formula
C22H31NO3
Oxybutynin
RX_link
http://www.rxlist.com/cgi/generic/ditropan.htm
Oxybutynin
fda sheet
Oxybutynin
msds (material safety sheet)
Oxybutynin
Synthesis Reference
Brit. pat. 940540 (1963 to Mead Johnson)
Oxybutynin
Molecular Weight
357.486 g/mol
Oxybutynin
Melting Point
129-130 oC
Oxybutynin
H2O Solubility
No information avaliable
Oxybutynin
State
Solid
Oxybutynin
LogP
4.683
Oxybutynin
Dosage Forms
Patch; Syrup; Tablet; Tablet (extended-release)
Oxybutynin
Indication
For the treatment of overactive bladder.
Oxybutynin
Pharmacology
Oxybutynin is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Oxybutynin relaxes bladder smooth muscle. Oxybutynin exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. Antimuscarinic activity resides predominantly in the R-isomer.
Oxybutynin
Absorption
Rapidly absorbed from gastrointestinal tract.
Oxybutynin
side effects and Toxicity
LD50=1220 mg/kg (Orally in rats, Goldenthal)
Oxybutynin
Patient Information
PATIENT INFORMATION
Patient should be informed that oxybutynin may produce drowsiness or blurred vision. Alcohal may enhance the drowsiness caused by anticholinergic agents. Fever and heat stroke can occur while anticholinergics are administered in the presence of high environmental temparature. Medication should be taken with the aid of liquids at approximately the same time each day. Patients should not chew, divide, or crush tablets.
Oxybutynin
Organisms Affected
Humans and other mammals