Oxybutynin Chloride
Brand names,
Oxybutynin Chloride
Analogs
Oxybutynin Chloride
Brand Names Mixture
Oxybutynin Chloride
Chemical_Formula
C22H31NO3
Oxybutynin Chloride
RX_link
http://www.rxlist.com/cgi/generic/ditropan.htm
Oxybutynin Chloride
fda sheet
Oxybutynin Chloride
msds (material safety sheet)
Oxybutynin Chloride
Synthesis Reference
Brit. pat. 940540 (1963 to Mead Johnson)
Oxybutynin Chloride
Molecular Weight
357.486 g/mol
Oxybutynin Chloride
Melting Point
129-130 oC
Oxybutynin Chloride
H2O Solubility
No information avaliable
Oxybutynin Chloride
State
Solid
Oxybutynin Chloride
LogP
4.683
Oxybutynin Chloride
Dosage Forms
Patch; Syrup; Tablet; Tablet (extended-release)
Oxybutynin Chloride
Indication
For the treatment of overactive bladder.
Oxybutynin Chloride
Pharmacology
Oxybutynin is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Oxybutynin relaxes bladder smooth muscle. Oxybutynin exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. Antimuscarinic activity resides predominantly in the R-isomer.
Oxybutynin Chloride
Absorption
Rapidly absorbed from gastrointestinal tract.
Oxybutynin Chloride
side effects and Toxicity
LD50=1220 mg/kg (Orally in rats, Goldenthal)
Oxybutynin Chloride
Patient Information
PATIENT INFORMATION
Patient should be informed that oxybutynin may produce drowsiness or blurred vision. Alcohal may enhance the drowsiness caused by anticholinergic agents. Fever and heat stroke can occur while anticholinergics are administered in the presence of high environmental temparature. Medication should be taken with the aid of liquids at approximately the same time each day. Patients should not chew, divide, or crush tablets.
Oxybutynin Chloride
Organisms Affected
Humans and other mammals