Oxybutinin
Brand names,
Oxybutinin
Analogs
Oxybutinin
Brand Names Mixture
Oxybutinin
Chemical_Formula
C22H31NO3
Oxybutinin
RX_link
http://www.rxlist.com/cgi/generic/ditropan.htm
Oxybutinin
fda sheet
Oxybutinin
msds (material safety sheet)
Oxybutinin
Synthesis Reference
Brit. pat. 940540 (1963 to Mead Johnson)
Oxybutinin
Molecular Weight
357.486 g/mol
Oxybutinin
Melting Point
129-130 oC
Oxybutinin
H2O Solubility
No information avaliable
Oxybutinin
State
Solid
Oxybutinin
LogP
4.683
Oxybutinin
Dosage Forms
Patch; Syrup; Tablet; Tablet (extended-release)
Oxybutinin
Indication
For the treatment of overactive bladder.
Oxybutinin
Pharmacology
Oxybutynin is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Oxybutynin relaxes bladder smooth muscle. Oxybutynin exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. Antimuscarinic activity resides predominantly in the R-isomer.
Oxybutinin
Absorption
Rapidly absorbed from gastrointestinal tract.
Oxybutinin
side effects and Toxicity
LD50=1220 mg/kg (Orally in rats, Goldenthal)
Oxybutinin
Patient Information
PATIENT INFORMATION
Patient should be informed that oxybutynin may produce drowsiness or blurred vision. Alcohal may enhance the drowsiness caused by anticholinergic agents. Fever and heat stroke can occur while anticholinergics are administered in the presence of high environmental temparature. Medication should be taken with the aid of liquids at approximately the same time each day. Patients should not chew, divide, or crush tablets.
Oxybutinin
Organisms Affected
Humans and other mammals