Oxybutynin Base
Brand names,
Oxybutynin Base
Analogs
Oxybutynin Base
Brand Names Mixture
Oxybutynin Base
Chemical_Formula
C22H31NO3
Oxybutynin Base
RX_link
http://www.rxlist.com/cgi/generic/ditropan.htm
Oxybutynin Base
fda sheet
Oxybutynin Base
msds (material safety sheet)
Oxybutynin Base
Synthesis Reference
Brit. pat. 940540 (1963 to Mead Johnson)
Oxybutynin Base
Molecular Weight
357.486 g/mol
Oxybutynin Base
Melting Point
129-130 oC
Oxybutynin Base
H2O Solubility
No information avaliable
Oxybutynin Base
State
Solid
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LogP
4.683
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Dosage Forms
Patch; Syrup; Tablet; Tablet (extended-release)
Oxybutynin Base
Indication
For the treatment of overactive bladder.
Oxybutynin Base
Pharmacology
Oxybutynin is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Oxybutynin relaxes bladder smooth muscle. Oxybutynin exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. Antimuscarinic activity resides predominantly in the R-isomer.
Oxybutynin Base
Absorption
Rapidly absorbed from gastrointestinal tract.
Oxybutynin Base
side effects and Toxicity
LD50=1220 mg/kg (Orally in rats, Goldenthal)
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Patient Information
PATIENT INFORMATION
Patient should be informed that oxybutynin may produce drowsiness or blurred vision. Alcohal may enhance the drowsiness caused by anticholinergic agents. Fever and heat stroke can occur while anticholinergics are administered in the presence of high environmental temparature. Medication should be taken with the aid of liquids at approximately the same time each day. Patients should not chew, divide, or crush tablets.
Oxybutynin Base
Organisms Affected
Humans and other mammals