Oxybutyninum [Inn-Latin]
Brand names,
Oxybutyninum [Inn-Latin]
Analogs
Oxybutyninum [Inn-Latin]
Brand Names Mixture
Oxybutyninum [Inn-Latin]
Chemical_Formula
C22H31NO3
Oxybutyninum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic/ditropan.htm
Oxybutyninum [Inn-Latin]
fda sheet
Oxybutyninum [Inn-Latin]
msds (material safety sheet)
Oxybutyninum [Inn-Latin]
Synthesis Reference
Brit. pat. 940540 (1963 to Mead Johnson)
Oxybutyninum [Inn-Latin]
Molecular Weight
357.486 g/mol
Oxybutyninum [Inn-Latin]
Melting Point
129-130 oC
Oxybutyninum [Inn-Latin]
H2O Solubility
No information avaliable
Oxybutyninum [Inn-Latin]
State
Solid
Oxybutyninum [Inn-Latin]
LogP
4.683
Oxybutyninum [Inn-Latin]
Dosage Forms
Patch; Syrup; Tablet; Tablet (extended-release)
Oxybutyninum [Inn-Latin]
Indication
For the treatment of overactive bladder.
Oxybutyninum [Inn-Latin]
Pharmacology
Oxybutynin is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Oxybutynin relaxes bladder smooth muscle. Oxybutynin exhibits only one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. Antimuscarinic activity resides predominantly in the R-isomer.
Oxybutyninum [Inn-Latin]
Absorption
Rapidly absorbed from gastrointestinal tract.
Oxybutyninum [Inn-Latin]
side effects and Toxicity
LD50=1220 mg/kg (Orally in rats, Goldenthal)
Oxybutyninum [Inn-Latin]
Patient Information
PATIENT INFORMATION
Patient should be informed that oxybutynin may produce drowsiness or blurred vision. Alcohal may enhance the drowsiness caused by anticholinergic agents. Fever and heat stroke can occur while anticholinergics are administered in the presence of high environmental temparature. Medication should be taken with the aid of liquids at approximately the same time each day. Patients should not chew, divide, or crush tablets.
Oxybutyninum [Inn-Latin]
Organisms Affected
Humans and other mammals