Mebendazole (JAN/USP)
Mebendazole (JAN/USP) Brand names, Mebendazole (JAN/USP) Analogs
Mebendazole (JAN/USP) Brand Names Mixture
- Absorbine JR Antifungal Liquid (menthol + tolnaftate)
Mebendazole (JAN/USP) Chemical_Formula
C9H18N2O4
Mebendazole (JAN/USP) RX_link
http://www.rxlist.com/cgi/generic2/meprobamate.htm
Mebendazole (JAN/USP) fda sheet
Mebendazole (JAN/USP) msds (material safety sheet)
Mebendazole (JAN/USP) Synthesis Reference
No information avaliable
Mebendazole (JAN/USP) Molecular Weight
218.25 g/mol
Mebendazole (JAN/USP) Melting Point
105 oC
Mebendazole (JAN/USP) H2O Solubility
4700 mg/L
Mebendazole (JAN/USP) State
Solid
Mebendazole (JAN/USP) LogP
0.092
Mebendazole (JAN/USP) Dosage Forms
Tablet for oral administration (200 mg, 400 mg)
Mebendazole (JAN/USP) Indication
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.
Mebendazole (JAN/USP) Pharmacology
Meprobamate is an anxiolytic drug. It was the best selling minor tranquilizer for a time but has largely been replaced by benzodiazepines. Meprobamate has most of the pharmacological effects and dangers of the barbiturates (though it was marketed as being safer). However, it is less sedating at effective doses. It is reported to have some anticonvulsant properties against absence seizures, but can exacerbate generalized tonic-clonic seizures. It has also been used as a hypnotic (sleeping pill). However, its is currently only licensed as an anxiolytic and it is a third or fourth-order choice.
Mebendazole (JAN/USP) Absorption
Well absorbed from the gastrointestinal tract.
Mebendazole (JAN/USP) side effects and Toxicity
Symptoms of overdose include coma, drowsiness, loss of muscle control, severely impaired breathing, shock, sluggishness, and unresponsiveness. Death has been reported with ingestion of as little as 12 g meprobamate and survival with as much as 40 g.
Mebendazole (JAN/USP) Patient Information
Mebendazole (JAN/USP) Organisms Affected
Humans and other mammals
