Iminourea
Iminourea Brand names, Iminourea Analogs
Iminourea Brand Names Mixture
- No information avaliable
Iminourea Chemical_Formula
CH5N3
Iminourea RX_link
No information avaliable
Iminourea fda sheet
Iminourea msds (material safety sheet)
Iminourea Synthesis Reference
No information avaliable
Iminourea Molecular Weight
59.0706 g/mol
Iminourea Melting Point
183 oC (HCl salt)
Iminourea H2O Solubility
500 mg/mL (HCl salt)
Iminourea State
Solid
Iminourea LogP
-0.946
Iminourea Dosage Forms
No information avaliable
Iminourea Indication
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Iminourea Pharmacology
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Iminourea Absorption
Rapidly absorbed and distributed
Iminourea side effects and Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Iminourea Patient Information
No information avaliable
Iminourea Organisms Affected
Humans and other mammals
