Aminomethanamidine
Aminomethanamidine Brand names, Aminomethanamidine Analogs
Aminomethanamidine Brand Names Mixture
- No information avaliable
Aminomethanamidine Chemical_Formula
CH5N3
Aminomethanamidine RX_link
No information avaliable
Aminomethanamidine fda sheet
Aminomethanamidine msds (material safety sheet)
Aminomethanamidine Synthesis Reference
No information avaliable
Aminomethanamidine Molecular Weight
59.0706 g/mol
Aminomethanamidine Melting Point
183 oC (HCl salt)
Aminomethanamidine H2O Solubility
500 mg/mL (HCl salt)
Aminomethanamidine State
Solid
Aminomethanamidine LogP
-0.946
Aminomethanamidine Dosage Forms
No information avaliable
Aminomethanamidine Indication
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Aminomethanamidine Pharmacology
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Aminomethanamidine Absorption
Rapidly absorbed and distributed
Aminomethanamidine side effects and Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Aminomethanamidine Patient Information
No information avaliable
Aminomethanamidine Organisms Affected
Humans and other mammals
