Carbamidine
Carbamidine Brand names, Carbamidine Analogs
Carbamidine Brand Names Mixture
- No information avaliable
Carbamidine Chemical_Formula
CH5N3
Carbamidine RX_link
No information avaliable
Carbamidine fda sheet
Carbamidine msds (material safety sheet)
Carbamidine Synthesis Reference
No information avaliable
Carbamidine Molecular Weight
59.0706 g/mol
Carbamidine Melting Point
183 oC (HCl salt)
Carbamidine H2O Solubility
500 mg/mL (HCl salt)
Carbamidine State
Solid
Carbamidine LogP
-0.946
Carbamidine Dosage Forms
No information avaliable
Carbamidine Indication
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Carbamidine Pharmacology
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Carbamidine Absorption
Rapidly absorbed and distributed
Carbamidine side effects and Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Carbamidine Patient Information
No information avaliable
Carbamidine Organisms Affected
Humans and other mammals
