Guanidin
Guanidin Brand names, Guanidin Analogs
Guanidin Brand Names Mixture
- No information avaliable
Guanidin Chemical_Formula
CH5N3
Guanidin RX_link
No information avaliable
Guanidin fda sheet
Guanidin msds (material safety sheet)
Guanidin Synthesis Reference
No information avaliable
Guanidin Molecular Weight
59.0706 g/mol
Guanidin Melting Point
183 oC (HCl salt)
Guanidin H2O Solubility
500 mg/mL (HCl salt)
Guanidin State
Solid
Guanidin LogP
-0.946
Guanidin Dosage Forms
No information avaliable
Guanidin Indication
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Guanidin Pharmacology
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Guanidin Absorption
Rapidly absorbed and distributed
Guanidin side effects and Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Guanidin Patient Information
No information avaliable
Guanidin Organisms Affected
Humans and other mammals
