Guanidine Hydrochloride
Guanidine Hydrochloride Brand names, Guanidine Hydrochloride Analogs
Guanidine Hydrochloride Brand Names Mixture
- No information avaliable
Guanidine Hydrochloride Chemical_Formula
CH5N3
Guanidine Hydrochloride RX_link
No information avaliable
Guanidine Hydrochloride fda sheet
Guanidine Hydrochloride msds (material safety sheet)
Guanidine Hydrochloride Synthesis Reference
No information avaliable
Guanidine Hydrochloride Molecular Weight
59.0706 g/mol
Guanidine Hydrochloride Melting Point
183 oC (HCl salt)
Guanidine Hydrochloride H2O Solubility
500 mg/mL (HCl salt)
Guanidine Hydrochloride State
Solid
Guanidine Hydrochloride LogP
-0.946
Guanidine Hydrochloride Dosage Forms
No information avaliable
Guanidine Hydrochloride Indication
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Guanidine Hydrochloride Pharmacology
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Guanidine Hydrochloride Absorption
Rapidly absorbed and distributed
Guanidine Hydrochloride side effects and Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Guanidine Hydrochloride Patient Information
No information avaliable
Guanidine Hydrochloride Organisms Affected
Humans and other mammals
