Carbamamidine
Carbamamidine Brand names, Carbamamidine Analogs
Carbamamidine Brand Names Mixture
- No information avaliable
Carbamamidine Chemical_Formula
CH5N3
Carbamamidine RX_link
No information avaliable
Carbamamidine fda sheet
Carbamamidine msds (material safety sheet)
Carbamamidine Synthesis Reference
No information avaliable
Carbamamidine Molecular Weight
59.0706 g/mol
Carbamamidine Melting Point
183 oC (HCl salt)
Carbamamidine H2O Solubility
500 mg/mL (HCl salt)
Carbamamidine State
Solid
Carbamamidine LogP
-0.946
Carbamamidine Dosage Forms
No information avaliable
Carbamamidine Indication
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Carbamamidine Pharmacology
Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
Carbamamidine Absorption
Rapidly absorbed and distributed
Carbamamidine side effects and Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Carbamamidine Patient Information
No information avaliable
Carbamamidine Organisms Affected
Humans and other mammals
