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Brand names,
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Analogs
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Brand Names Mixture
- Viskazide 10/25tab (Hydrochlorothiazide + Pindolol)
- Viskazide 10/50tab (Hydrochlorothiazide + Pindolol)
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Chemical_Formula
C14H20N2O2
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RX_link
http://www.rxlist.com/cgi/generic3/pindolol.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
248.321 g/mol
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Melting Point
167-171 oC
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H2O Solubility
7880 mg/L
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State
Solid
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LogP
2.525
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Dosage Forms
Tablet
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Indication
For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
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Pharmacology
Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity. Pindolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Pindolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Pindolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, pindolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
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Absorption
Rapidly and reproducibly absorbed (bioavailability greater than 95%).
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side effects and Toxicity
LD50=263 mg/kg (orally in rats). Signs of overdose include excessive bradycardia, cardiac failure, hypotension, and bronchospasm.
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Patient Information
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Organisms Affected
Humans and other mammals