Pynastin
Pynastin Brand names, Pynastin Analogs
Pynastin Brand Names Mixture
- Viskazide 10/25tab (Hydrochlorothiazide + Pindolol)
- Viskazide 10/50tab (Hydrochlorothiazide + Pindolol)
Pynastin Chemical_Formula
C14H20N2O2
Pynastin RX_link
http://www.rxlist.com/cgi/generic3/pindolol.htm
Pynastin fda sheet
Pynastin msds (material safety sheet)
Pynastin Synthesis Reference
No information avaliable
Pynastin Molecular Weight
248.321 g/mol
Pynastin Melting Point
167-171 oC
Pynastin H2O Solubility
7880 mg/L
Pynastin State
Solid
Pynastin LogP
2.525
Pynastin Dosage Forms
Tablet
Pynastin Indication
For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
Pynastin Pharmacology
Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity. Pindolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Pindolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Pindolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, pindolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
Pynastin Absorption
Rapidly and reproducibly absorbed (bioavailability greater than 95%).
Pynastin side effects and Toxicity
LD50=263 mg/kg (orally in rats). Signs of overdose include excessive bradycardia, cardiac failure, hypotension, and bronchospasm.
Pynastin Patient Information
Pynastin Organisms Affected
Humans and other mammals
