Fosamax
Fosamax Brand names, Fosamax Analogs
Fosamax Brand Names Mixture
- No information avaliable
Fosamax Chemical_Formula
C4H13NO7P2
Fosamax RX_link
http://www.rxlist.com/cgi/generic/alendron.htm
Fosamax fda sheet
Fosamax msds (material safety sheet)
Fosamax Synthesis Reference
M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)
Fosamax Molecular Weight
249.096 g/mol
Fosamax Melting Point
233 - 235 oC
Fosamax H2O Solubility
1mg/L
Fosamax State
Solid
Fosamax LogP
-3.198
Fosamax Dosage Forms
Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)
Fosamax Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Fosamax Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Fosamax Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Fosamax side effects and Toxicity
Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."
Fosamax Patient Information
Fosamax Organisms Affected
Humans and other mammals
