Arendal
Arendal Brand names, Arendal Analogs
Arendal Brand Names Mixture
- No information avaliable
Arendal Chemical_Formula
C4H13NO7P2
Arendal RX_link
http://www.rxlist.com/cgi/generic/alendron.htm
Arendal fda sheet
Arendal msds (material safety sheet)
Arendal Synthesis Reference
M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)
Arendal Molecular Weight
249.096 g/mol
Arendal Melting Point
233 - 235 oC
Arendal H2O Solubility
1mg/L
Arendal State
Solid
Arendal LogP
-3.198
Arendal Dosage Forms
Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)
Arendal Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Arendal Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Arendal Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Arendal side effects and Toxicity
Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."
Arendal Patient Information
Arendal Organisms Affected
Humans and other mammals
