Adronat
Adronat Brand names, Adronat Analogs
Adronat Brand Names Mixture
- No information avaliable
Adronat Chemical_Formula
C4H13NO7P2
Adronat RX_link
http://www.rxlist.com/cgi/generic/alendron.htm
Adronat fda sheet
Adronat msds (material safety sheet)
Adronat Synthesis Reference
M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)
Adronat Molecular Weight
249.096 g/mol
Adronat Melting Point
233 - 235 oC
Adronat H2O Solubility
1mg/L
Adronat State
Solid
Adronat LogP
-3.198
Adronat Dosage Forms
Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)
Adronat Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Adronat Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Adronat Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Adronat side effects and Toxicity
Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."
Adronat Patient Information
Adronat Organisms Affected
Humans and other mammals
