Alendronic acid
Alendronic acid Brand names, Alendronic acid Analogs
Alendronic acid Brand Names Mixture
- No information avaliable
Alendronic acid Chemical_Formula
C4H13NO7P2
Alendronic acid RX_link
http://www.rxlist.com/cgi/generic/alendron.htm
Alendronic acid fda sheet
Alendronic acid msds (material safety sheet)
Alendronic acid Synthesis Reference
M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)
Alendronic acid Molecular Weight
249.096 g/mol
Alendronic acid Melting Point
233 - 235 oC
Alendronic acid H2O Solubility
1mg/L
Alendronic acid State
Solid
Alendronic acid LogP
-3.198
Alendronic acid Dosage Forms
Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)
Alendronic acid Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Alendronic acid Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Alendronic acid Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Alendronic acid side effects and Toxicity
Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."
Alendronic acid Patient Information
Alendronic acid Organisms Affected
Humans and other mammals
