Acido Alendronico [Inn-Spanish]

Acido Alendronico [Inn-Spanish] Brand names, Acido Alendronico [Inn-Spanish] Analogs

Acido Alendronico [Inn-Spanish] Brand Names Mixture

No information avaliable

Acido Alendronico [Inn-Spanish] Chemical_Formula

C₄H₁₃NO₇P₂

Acido Alendronico [Inn-Spanish] RX_link

http://www.rxlist.com/cgi/generic/alendron.htm

Acido Alendronico [Inn-Spanish] fda sheet

Acido_Alendronico_[Inn-Spanish] FDA

Acido Alendronico [Inn-Spanish] msds (material safety sheet)

Acido_Alendronico_[Inn-Spanish] MSDS

Acido Alendronico [Inn-Spanish] Synthesis Reference

M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)

Acido Alendronico [Inn-Spanish] Molecular Weight

249.096 g/mol

Acido Alendronico [Inn-Spanish] Melting Point

233 - 235 ^oC

Acido Alendronico [Inn-Spanish] H₂O Solubility

1mg/L

Acido Alendronico [Inn-Spanish] State

Solid

Acido Alendronico [Inn-Spanish] LogP

-3.198

Acido Alendronico [Inn-Spanish] Dosage Forms

Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)

Acido Alendronico [Inn-Spanish] Indication

For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.

Acido Alendronico [Inn-Spanish] Pharmacology

Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.

Acido Alendronico [Inn-Spanish] Absorption

Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.

Acido Alendronico [Inn-Spanish] side effects and Toxicity

Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."

Acido Alendronico [Inn-Spanish] Patient Information

Acido Alendronico [Inn-Spanish] Organisms Affected

Humans and other mammals