Alendronate Sodium
Alendronate Sodium Brand names, Alendronate Sodium Analogs
Alendronate Sodium Brand Names Mixture
- No information avaliable
Alendronate Sodium Chemical_Formula
C4H13NO7P2
Alendronate Sodium RX_link
http://www.rxlist.com/cgi/generic/alendron.htm
Alendronate Sodium fda sheet
Alendronate Sodium msds (material safety sheet)
Alendronate Sodium Synthesis Reference
M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)
Alendronate Sodium Molecular Weight
249.096 g/mol
Alendronate Sodium Melting Point
233 - 235 oC
Alendronate Sodium H2O Solubility
1mg/L
Alendronate Sodium State
Solid
Alendronate Sodium LogP
-3.198
Alendronate Sodium Dosage Forms
Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)
Alendronate Sodium Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Alendronate Sodium Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Alendronate Sodium Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Alendronate Sodium side effects and Toxicity
Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."
Alendronate Sodium Patient Information
Alendronate Sodium Organisms Affected
Humans and other mammals
