Acide Alendronique [Inn-French]
Brand names,
Acide Alendronique [Inn-French]
Analogs
Acide Alendronique [Inn-French]
Brand Names Mixture
Acide Alendronique [Inn-French]
Chemical_Formula
C4H13NO7P2
Acide Alendronique [Inn-French]
RX_link
http://www.rxlist.com/cgi/generic/alendron.htm
Acide Alendronique [Inn-French]
fda sheet
Acide Alendronique [Inn-French]
msds (material safety sheet)
Acide Alendronique [Inn-French]
Synthesis Reference
M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)
Acide Alendronique [Inn-French]
Molecular Weight
249.096 g/mol
Acide Alendronique [Inn-French]
Melting Point
233 - 235 oC
Acide Alendronique [Inn-French]
H2O Solubility
1mg/L
Acide Alendronique [Inn-French]
State
Solid
Acide Alendronique [Inn-French]
LogP
-3.198
Acide Alendronique [Inn-French]
Dosage Forms
Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)
Acide Alendronique [Inn-French]
Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Acide Alendronique [Inn-French]
Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Acide Alendronique [Inn-French]
Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Acide Alendronique [Inn-French]
side effects and Toxicity
Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."
Acide Alendronique [Inn-French]
Patient Information
Acide Alendronique [Inn-French]
Organisms Affected
Humans and other mammals