PharmacyCodes



Dipivefrine en es it fr

Dipivefrine Brand names, Dipivefrine Analogs

Dipivefrine Brand Names Mixture

  • No information avaliable

Dipivefrine Chemical_Formula

C19H29NO5

Dipivefrine RX_link

http://www.rxlist.com/cgi/generic2/dipivefrin.htm

Dipivefrine fda sheet

Dipivefrine FDA

Dipivefrine msds (material safety sheet)

Dipivefrine MSDS

Dipivefrine Synthesis Reference

No information avaliable

Dipivefrine Molecular Weight

351.437 g/mol

Dipivefrine Melting Point

No information avaliable

Dipivefrine H2O Solubility

Freely soluble as HCl salt

Dipivefrine State

Solid

Dipivefrine LogP

4.354

Dipivefrine Dosage Forms

Drops; Liquid; Solution

Dipivefrine Indication

Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

Dipivefrine Pharmacology

Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.

Dipivefrine Absorption

Well absorbed following occular administration.

Dipivefrine side effects and Toxicity

Oral LD50 in rat is 183 mg/kg.

Dipivefrine Patient Information

No information avaliable

Dipivefrine Organisms Affected

Humans and other mammals