Dipivefrine
Dipivefrine Brand names, Dipivefrine Analogs
Dipivefrine Brand Names Mixture
- No information avaliable
Dipivefrine Chemical_Formula
C19H29NO5
Dipivefrine RX_link
http://www.rxlist.com/cgi/generic2/dipivefrin.htm
Dipivefrine fda sheet
Dipivefrine msds (material safety sheet)
Dipivefrine Synthesis Reference
No information avaliable
Dipivefrine Molecular Weight
351.437 g/mol
Dipivefrine Melting Point
No information avaliable
Dipivefrine H2O Solubility
Freely soluble as HCl salt
Dipivefrine State
Solid
Dipivefrine LogP
4.354
Dipivefrine Dosage Forms
Drops; Liquid; Solution
Dipivefrine Indication
Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
Dipivefrine Pharmacology
Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.
Dipivefrine Absorption
Well absorbed following occular administration.
Dipivefrine side effects and Toxicity
Oral LD50 in rat is 183 mg/kg.
Dipivefrine Patient Information
No information avaliable
Dipivefrine Organisms Affected
Humans and other mammals
