PharmacyCodes



Dipivefrinum [INN-Latin] en es it fr

Dipivefrinum [INN-Latin] Brand names, Dipivefrinum [INN-Latin] Analogs

Dipivefrinum [INN-Latin] Brand Names Mixture

  • No information avaliable

Dipivefrinum [INN-Latin] Chemical_Formula

C19H29NO5

Dipivefrinum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic2/dipivefrin.htm

Dipivefrinum [INN-Latin] fda sheet

Dipivefrinum_[INN-Latin] FDA

Dipivefrinum [INN-Latin] msds (material safety sheet)

Dipivefrinum_[INN-Latin] MSDS

Dipivefrinum [INN-Latin] Synthesis Reference

No information avaliable

Dipivefrinum [INN-Latin] Molecular Weight

351.437 g/mol

Dipivefrinum [INN-Latin] Melting Point

No information avaliable

Dipivefrinum [INN-Latin] H2O Solubility

Freely soluble as HCl salt

Dipivefrinum [INN-Latin] State

Solid

Dipivefrinum [INN-Latin] LogP

4.354

Dipivefrinum [INN-Latin] Dosage Forms

Drops; Liquid; Solution

Dipivefrinum [INN-Latin] Indication

Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

Dipivefrinum [INN-Latin] Pharmacology

Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.

Dipivefrinum [INN-Latin] Absorption

Well absorbed following occular administration.

Dipivefrinum [INN-Latin] side effects and Toxicity

Oral LD50 in rat is 183 mg/kg.

Dipivefrinum [INN-Latin] Patient Information

No information avaliable

Dipivefrinum [INN-Latin] Organisms Affected

Humans and other mammals