Dipivefrin HCL
Dipivefrin HCL Brand names, Dipivefrin HCL Analogs
Dipivefrin HCL Brand Names Mixture
- No information avaliable
Dipivefrin HCL Chemical_Formula
C19H29NO5
Dipivefrin HCL RX_link
http://www.rxlist.com/cgi/generic2/dipivefrin.htm
Dipivefrin HCL fda sheet
Dipivefrin HCL msds (material safety sheet)
Dipivefrin HCL Synthesis Reference
No information avaliable
Dipivefrin HCL Molecular Weight
351.437 g/mol
Dipivefrin HCL Melting Point
No information avaliable
Dipivefrin HCL H2O Solubility
Freely soluble as HCl salt
Dipivefrin HCL State
Solid
Dipivefrin HCL LogP
4.354
Dipivefrin HCL Dosage Forms
Drops; Liquid; Solution
Dipivefrin HCL Indication
Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
Dipivefrin HCL Pharmacology
Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.
Dipivefrin HCL Absorption
Well absorbed following occular administration.
Dipivefrin HCL side effects and Toxicity
Oral LD50 in rat is 183 mg/kg.
Dipivefrin HCL Patient Information
No information avaliable
Dipivefrin HCL Organisms Affected
Humans and other mammals
