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Propine Brand names, Propine Analogs

Propine Brand Names Mixture

  • No information avaliable

Propine Chemical_Formula


Propine RX_link

Propine fda sheet

Propine FDA

Propine msds (material safety sheet)

Propine MSDS

Propine Synthesis Reference

No information avaliable

Propine Molecular Weight

351.437 g/mol

Propine Melting Point

No information avaliable

Propine H2O Solubility

Freely soluble as HCl salt

Propine State


Propine LogP


Propine Dosage Forms

Drops; Liquid; Solution

Propine Indication

Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

Propine Pharmacology

Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.

Propine Absorption

Well absorbed following occular administration.

Propine side effects and Toxicity

Oral LD50 in rat is 183 mg/kg.

Propine Patient Information

No information avaliable

Propine Organisms Affected

Humans and other mammals