Propine
Propine Brand names, Propine Analogs
Propine Brand Names Mixture
- No information avaliable
Propine Chemical_Formula
C19H29NO5
Propine RX_link
http://www.rxlist.com/cgi/generic2/dipivefrin.htm
Propine fda sheet
Propine msds (material safety sheet)
Propine Synthesis Reference
No information avaliable
Propine Molecular Weight
351.437 g/mol
Propine Melting Point
No information avaliable
Propine H2O Solubility
Freely soluble as HCl salt
Propine State
Solid
Propine LogP
4.354
Propine Dosage Forms
Drops; Liquid; Solution
Propine Indication
Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
Propine Pharmacology
Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.
Propine Absorption
Well absorbed following occular administration.
Propine side effects and Toxicity
Oral LD50 in rat is 183 mg/kg.
Propine Patient Information
No information avaliable
Propine Organisms Affected
Humans and other mammals
