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DPE Brand names, DPE Analogs

DPE Brand Names Mixture

  • No information avaliable

DPE Chemical_Formula


DPE RX_link


DPE fda sheet


DPE msds (material safety sheet)


DPE Synthesis Reference

No information avaliable

DPE Molecular Weight

351.437 g/mol

DPE Melting Point

No information avaliable

DPE H2O Solubility

Freely soluble as HCl salt

DPE State




DPE Dosage Forms

Drops; Liquid; Solution

DPE Indication

Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

DPE Pharmacology

Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.

DPE Absorption

Well absorbed following occular administration.

DPE side effects and Toxicity

Oral LD50 in rat is 183 mg/kg.

DPE Patient Information

No information avaliable

DPE Organisms Affected

Humans and other mammals