DPE
DPE Brand names, DPE Analogs
DPE Brand Names Mixture
- No information avaliable
DPE Chemical_Formula
C19H29NO5
DPE RX_link
http://www.rxlist.com/cgi/generic2/dipivefrin.htm
DPE fda sheet
DPE msds (material safety sheet)
DPE Synthesis Reference
No information avaliable
DPE Molecular Weight
351.437 g/mol
DPE Melting Point
No information avaliable
DPE H2O Solubility
Freely soluble as HCl salt
DPE State
Solid
DPE LogP
4.354
DPE Dosage Forms
Drops; Liquid; Solution
DPE Indication
Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
DPE Pharmacology
Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.
DPE Absorption
Well absorbed following occular administration.
DPE side effects and Toxicity
Oral LD50 in rat is 183 mg/kg.
DPE Patient Information
No information avaliable
DPE Organisms Affected
Humans and other mammals
