Ophtho-Dipivefrin
Ophtho-Dipivefrin Brand names, Ophtho-Dipivefrin Analogs
Ophtho-Dipivefrin Brand Names Mixture
- No information avaliable
Ophtho-Dipivefrin Chemical_Formula
C19H29NO5
Ophtho-Dipivefrin RX_link
http://www.rxlist.com/cgi/generic2/dipivefrin.htm
Ophtho-Dipivefrin fda sheet
Ophtho-Dipivefrin msds (material safety sheet)
Ophtho-Dipivefrin Synthesis Reference
No information avaliable
Ophtho-Dipivefrin Molecular Weight
351.437 g/mol
Ophtho-Dipivefrin Melting Point
No information avaliable
Ophtho-Dipivefrin H2O Solubility
Freely soluble as HCl salt
Ophtho-Dipivefrin State
Solid
Ophtho-Dipivefrin LogP
4.354
Ophtho-Dipivefrin Dosage Forms
Drops; Liquid; Solution
Ophtho-Dipivefrin Indication
Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
Ophtho-Dipivefrin Pharmacology
Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.
Ophtho-Dipivefrin Absorption
Well absorbed following occular administration.
Ophtho-Dipivefrin side effects and Toxicity
Oral LD50 in rat is 183 mg/kg.
Ophtho-Dipivefrin Patient Information
No information avaliable
Ophtho-Dipivefrin Organisms Affected
Humans and other mammals
