AKPro
AKPro Brand names, AKPro Analogs
AKPro Brand Names Mixture
- No information avaliable
AKPro Chemical_Formula
C19H29NO5
AKPro RX_link
http://www.rxlist.com/cgi/generic2/dipivefrin.htm
AKPro fda sheet
AKPro msds (material safety sheet)
AKPro Synthesis Reference
No information avaliable
AKPro Molecular Weight
351.437 g/mol
AKPro Melting Point
No information avaliable
AKPro H2O Solubility
Freely soluble as HCl salt
AKPro State
Solid
AKPro LogP
4.354
AKPro Dosage Forms
Drops; Liquid; Solution
AKPro Indication
Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
AKPro Pharmacology
Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.
AKPro Absorption
Well absorbed following occular administration.
AKPro side effects and Toxicity
Oral LD50 in rat is 183 mg/kg.
AKPro Patient Information
No information avaliable
AKPro Organisms Affected
Humans and other mammals
