PharmacyCodes



Dipivefrina [INN-Spanish] en es it fr

Dipivefrina [INN-Spanish] Brand names, Dipivefrina [INN-Spanish] Analogs

Dipivefrina [INN-Spanish] Brand Names Mixture

  • No information avaliable

Dipivefrina [INN-Spanish] Chemical_Formula

C19H29NO5

Dipivefrina [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/dipivefrin.htm

Dipivefrina [INN-Spanish] fda sheet

Dipivefrina_[INN-Spanish] FDA

Dipivefrina [INN-Spanish] msds (material safety sheet)

Dipivefrina_[INN-Spanish] MSDS

Dipivefrina [INN-Spanish] Synthesis Reference

No information avaliable

Dipivefrina [INN-Spanish] Molecular Weight

351.437 g/mol

Dipivefrina [INN-Spanish] Melting Point

No information avaliable

Dipivefrina [INN-Spanish] H2O Solubility

Freely soluble as HCl salt

Dipivefrina [INN-Spanish] State

Solid

Dipivefrina [INN-Spanish] LogP

4.354

Dipivefrina [INN-Spanish] Dosage Forms

Drops; Liquid; Solution

Dipivefrina [INN-Spanish] Indication

Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

Dipivefrina [INN-Spanish] Pharmacology

Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.

Dipivefrina [INN-Spanish] Absorption

Well absorbed following occular administration.

Dipivefrina [INN-Spanish] side effects and Toxicity

Oral LD50 in rat is 183 mg/kg.

Dipivefrina [INN-Spanish] Patient Information

No information avaliable

Dipivefrina [INN-Spanish] Organisms Affected

Humans and other mammals