Griseofulvin-forte
Category
Griseofulvin-forte Brand names, Griseofulvin-forte Analogs
Griseofulvin-forte Brand Names Mixture
Griseofulvin-forte Chemical_Formula
C17H17ClO6
Griseofulvin-forte RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Griseofulvin-forte fda sheet
Griseofulvin-forte msds (material safety sheet)
Griseofulvin-forte Synthesis Reference
No information avaliable
Griseofulvin-forte Molecular Weight
352.766 g/mol
Griseofulvin-forte Melting Point
220 oC
Griseofulvin-forte H2O Solubility
8.64 mg/L
Griseofulvin-forte State
Solid
Griseofulvin-forte LogP
2.15
Griseofulvin-forte Dosage Forms
Powder; Tablet
Griseofulvin-forte Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Griseofulvin-forte Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Griseofulvin-forte Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Griseofulvin-forte side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Griseofulvin-forte Patient Information
Griseofulvin-forte Organisms Affected
Yeast and other Trichophyton or Microsporum fungi
