Likunden
Category
Likunden Brand names, Likunden Analogs
Likunden Brand Names Mixture
Likunden Chemical_Formula
C17H17ClO6
Likunden RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Likunden fda sheet
Likunden msds (material safety sheet)
Likunden Synthesis Reference
No information avaliable
Likunden Molecular Weight
352.766 g/mol
Likunden Melting Point
220 oC
Likunden H2O Solubility
8.64 mg/L
Likunden State
Solid
Likunden LogP
2.15
Likunden Dosage Forms
Powder; Tablet
Likunden Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Likunden Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Likunden Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Likunden side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Likunden Patient Information
Likunden Organisms Affected
Yeast and other Trichophyton or Microsporum fungi
