Fulcin
Category
Fulcin Brand names, Fulcin Analogs
Fulcin Brand Names Mixture
Fulcin Chemical_Formula
C17H17ClO6
Fulcin RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Fulcin fda sheet
Fulcin msds (material safety sheet)
Fulcin Synthesis Reference
No information avaliable
Fulcin Molecular Weight
352.766 g/mol
Fulcin Melting Point
220 oC
Fulcin H2O Solubility
8.64 mg/L
Fulcin State
Solid
Fulcin LogP
2.15
Fulcin Dosage Forms
Powder; Tablet
Fulcin Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Fulcin Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Fulcin Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Fulcin side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Fulcin Patient Information
Fulcin Organisms Affected
Yeast and other Trichophyton or Microsporum fungi
