Xuanjing
Category
Xuanjing Brand names, Xuanjing Analogs
Xuanjing Brand Names Mixture
Xuanjing Chemical_Formula
C17H17ClO6
Xuanjing RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Xuanjing fda sheet
Xuanjing msds (material safety sheet)
Xuanjing Synthesis Reference
No information avaliable
Xuanjing Molecular Weight
352.766 g/mol
Xuanjing Melting Point
220 oC
Xuanjing H2O Solubility
8.64 mg/L
Xuanjing State
Solid
Xuanjing LogP
2.15
Xuanjing Dosage Forms
Powder; Tablet
Xuanjing Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Xuanjing Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Xuanjing Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Xuanjing side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Xuanjing Patient Information
Xuanjing Organisms Affected
Yeast and other Trichophyton or Microsporum fungi
