Gricin
Category
Gricin Brand names, Gricin Analogs
Gricin Brand Names Mixture
Gricin Chemical_Formula
C17H17ClO6
Gricin RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Gricin fda sheet
Gricin msds (material safety sheet)
Gricin Synthesis Reference
No information avaliable
Gricin Molecular Weight
352.766 g/mol
Gricin Melting Point
220 oC
Gricin H2O Solubility
8.64 mg/L
Gricin State
Solid
Gricin LogP
2.15
Gricin Dosage Forms
Powder; Tablet
Gricin Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Gricin Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Gricin Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Gricin side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Gricin Patient Information
Gricin Organisms Affected
Yeast and other Trichophyton or Microsporum fungi
