Gris-PEG
Category
Gris-PEG Brand names, Gris-PEG Analogs
Gris-PEG Brand Names Mixture
Gris-PEG Chemical_Formula
C17H17ClO6
Gris-PEG RX_link
http://www.rxlist.com/cgi/generic3/griseofulvin.htm
Gris-PEG fda sheet
Gris-PEG msds (material safety sheet)
Gris-PEG Synthesis Reference
No information avaliable
Gris-PEG Molecular Weight
352.766 g/mol
Gris-PEG Melting Point
220 oC
Gris-PEG H2O Solubility
8.64 mg/L
Gris-PEG State
Solid
Gris-PEG LogP
2.15
Gris-PEG Dosage Forms
Powder; Tablet
Gris-PEG Indication
For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by Trichophyton or Microsporum fungi.
Gris-PEG Pharmacology
Griseofulvin is a mycotoxic metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. Griseofulvin is fungistatic with in vitro activity against various species of Microsporum Epidermophyton, and Trichophyton. It has no effect on bacteria or on other genera of fungi. Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.
Gris-PEG Absorption
Poorly absorbed from GI ranging from 25 to 70% of an oral dose. Absorption is significantly enhanced by administration with or after a fatty meal.
Gris-PEG side effects and Toxicity
Side effects are minor: headaches, gastrointestinal reactions and cutaneous eruptions
Gris-PEG Patient Information
Gris-PEG Organisms Affected
Yeast and other Trichophyton or Microsporum fungi
