Categorie
Lopresor
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Analogs
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Les marques melange
LOPRESSOR HCT
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Formule chimique
C15H25NO3
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RX lien
http://www.rxlist.com/cgi/generic/metopxl.htm
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FDA fiche
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msds (fiche de securite des materiaux)
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Synthese de reference
AE Brandstorm et al., US. 3,873,600 (1975)
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Poids moleculaire
267.364 g/mol
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Point de fusion
120 oC (tartarate salt)
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H2O Solubilite
16,9 mg / ml
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Etat
Solid
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LogP
2.477
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Formes pharmaceutiques
Tablet
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Indication
Pour le traitement de l'hypertension et l'angine de poitrine.
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Pharmacologie
Métoprolol, un antagoniste compétitif, beta1-adrénergiques sélectifs (cardiosélectif), est similaire à l'aténolol dans sa liposolubilité modérée, manque d'activité sympathomimétique intrinsèque (ASI), et la membrane faibles stabilisation de l'activité (MSA).
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Absorption
Rapide et complète, 50%
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Toxicite
DL50 = 5500 mg / kg (par voie orale chez le rat), les effets toxiques incluent la bradycardie, l'hypotension, bronchospasme et insuffisance cardiaque. DL50 = 2090 mg / kg (par voie orale chez la souris)
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Information pour les patients
Metoprolol succinate is used to treat high blood pressure alone or in combination with other medications. This
medication can also be used to treat a heart condition called angina. This particular formulation is an extended
release product, meaning it can be taken once a day. This medication should be taken as directed, with a meal or
right after a meal. The tablets should not be broken or crushed. Do not take a double dose if a dose is missed. This
medication should not be stopped abruptly; it should be discontinued slowly over time. If you are taking this
medication for high blood pressure, make sure to have your blood pressure checked regularly. If you ever have trouble
breathing, call your physician immediately. The most common adverse effects are dizziness and tiredness. It is
important to inform all your healthcare providers that you are taking this medication, especially before any
surgeries or procedures.
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Organismes affectes
Les humains et autres mammifères