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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C15H25NO3
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RX_link
http://www.rxlist.com/cgi/generic/metopxl.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
A. E. Brandstorm et al., U.S. Pat. 3,873,600 (1975)
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Molecular Weight
267.364 g/mol
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Melting Point
120 oC (tartarate salt)
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H2O Solubility
16.9 mg/mL
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State
Solid
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LogP
2.477
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Dosage Forms
Tablet
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Indication
For the treatment of hypertension and angina pectoris.
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Pharmacology
Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).
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Absorption
Rapid and complete, 50%
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side effects and Toxicity
LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)
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Patient Information
Metoprolol succinate is used to treat high blood pressure alone or in combination with other medications. This
medication can also be used to treat a heart condition called angina. This particular formulation is an extended
release product, meaning it can be taken once a day. This medication should be taken as directed, with a meal or
right after a meal. The tablets should not be broken or crushed. Do not take a double dose if a dose is missed. This
medication should not be stopped abruptly; it should be discontinued slowly over time. If you are taking this
medication for high blood pressure, make sure to have your blood pressure checked regularly. If you ever have trouble
breathing, call your physician immediately. The most common adverse effects are dizziness and tiredness. It is
important to inform all your healthcare providers that you are taking this medication, especially before any
surgeries or procedures.
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Organisms Affected
Humans and other mammals