Prelis

Prelis Brand names, Prelis Analogs

Prelis Brand Names Mixture

LOPRESSOR HCT

Prelis Chemical_Formula

C₁₅H₂₅NO₃

Prelis RX_link

http://www.rxlist.com/cgi/generic/metopxl.htm

Prelis fda sheet

Prelis FDA

Prelis msds (material safety sheet)

Prelis MSDS

Prelis Synthesis Reference

A. E. Brandstorm et al., U.S. Pat. 3,873,600 (1975)

Prelis Molecular Weight

267.364 g/mol

Prelis Melting Point

120 ^oC (tartarate salt)

Prelis H₂O Solubility

16.9 mg/mL

Prelis State

Solid

Prelis LogP

2.477

Prelis Dosage Forms

Tablet

Prelis Indication

For the treatment of hypertension and angina pectoris.

Prelis Pharmacology

Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).

Prelis Absorption

Rapid and complete, 50%

Prelis side effects and Toxicity

LD₅₀=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD₅₀=2090 mg/kg (orally in mice)

Prelis Patient Information

Metoprolol succinate is used to treat high blood pressure alone or in combination with other medications. This medication can also be used to treat a heart condition called angina. This particular formulation is an extended release product, meaning it can be taken once a day. This medication should be taken as directed, with a meal or right after a meal. The tablets should not be broken or crushed. Do not take a double dose if a dose is missed. This medication should not be stopped abruptly; it should be discontinued slowly over time. If you are taking this medication for high blood pressure, make sure to have your blood pressure checked regularly. If you ever have trouble breathing, call your physician immediately. The most common adverse effects are dizziness and tiredness. It is important to inform all your healthcare providers that you are taking this medication, especially before any surgeries or procedures.

Prelis Organisms Affected

Humans and other mammals