Categoria
Metroprolol
Nombres de marca,
Metroprolol
Analogos
Metroprolol
Marca los nombres de mezcla
LOPRESSOR HCT
Metroprolol
Formula quimica
C15H25NO3
Metroprolol
RX enlace
http://www.rxlist.com/cgi/generic/metopxl.htm
Metroprolol
FDA hoja
Metroprolol
MSDS (hoja de seguridad de materiales)
Metroprolol
Sintesis de referencia
AE Brandstorm et al., Patente de EE.UU.. 3,873,600 (1975)
Metroprolol
Peso molecular
267.364 g/mol
Metroprolol
Punto de fusion
120 oC (tartarate salt)
Metroprolol
H2O Solubilidad
16,9 mg / ml
Metroprolol
Estado
Solid
Metroprolol
LogP
2.477
Metroprolol
Formas de dosificacion
Tableta
Metroprolol
Indicacion
Para el tratamiento de la hipertensión y la angina de pecho.
Metroprolol
Farmacologia
Metoprolol, un antagonista competitivo, adrenérgicos beta1-selectivo (cardioselectivo), es similar a atenolol en su moderada solubilidad en lípidos, la falta de actividad simpaticomimética intrínseca (ISA), y la membrana débil estabilización de la actividad (MSA).
Metroprolol
Absorcion
Rápida y completa, el 50%
Metroprolol
Toxicidad
DL50 = 5500 mg / kg (por vía oral en ratas), efectos tóxicos incluyen bradicardia, hipotensión, broncoespasmo e insuficiencia cardiaca. DL50 = 2090 mg / kg (por vía oral en ratones)
Metroprolol
Informacion de Pacientes
Metoprolol succinate is used to treat high blood pressure alone or in combination with other medications. This
medication can also be used to treat a heart condition called angina. This particular formulation is an extended
release product, meaning it can be taken once a day. This medication should be taken as directed, with a meal or
right after a meal. The tablets should not be broken or crushed. Do not take a double dose if a dose is missed. This
medication should not be stopped abruptly; it should be discontinued slowly over time. If you are taking this
medication for high blood pressure, make sure to have your blood pressure checked regularly. If you ever have trouble
breathing, call your physician immediately. The most common adverse effects are dizziness and tiredness. It is
important to inform all your healthcare providers that you are taking this medication, especially before any
surgeries or procedures.
Metroprolol
Organismos afectados
Humanos y otros mamíferos