Vinblastine

Vinblastine Brand names, Vinblastine Analogs

Vinblastine Brand Names Mixture

No information avaliable

Vinblastine Chemical_Formula

C₄₆H₅₈N₄O₉

Vinblastine RX_link

http://www.rxlist.com/cgi/generic3/vinblastine.htm

Vinblastine fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=29

Vinblastine msds (material safety sheet)

Vinblastine MSDS

Vinblastine Synthesis Reference

No information avaliable

Vinblastine Molecular Weight

810.974 g/mol

Vinblastine Melting Point

267 ^oC

Vinblastine H₂O Solubility

Negligible

Vinblastine State

Solid

Vinblastine LogP

5.587

Vinblastine Dosage Forms

Liquid; Powder for solution; Solution

Vinblastine Indication

For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Vinblastine Pharmacology

Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Vinblastine Absorption