Vinblastin

Vinblastin Brand names, Vinblastin Analogs

Vinblastin Brand Names Mixture

No information avaliable

Vinblastin Chemical_Formula

C₄₆H₅₈N₄O₉

Vinblastin RX_link

http://www.rxlist.com/cgi/generic3/vinblastine.htm

Vinblastin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=29

Vinblastin msds (material safety sheet)

Vinblastin MSDS

Vinblastin Synthesis Reference

No information avaliable

Vinblastin Molecular Weight

810.974 g/mol

Vinblastin Melting Point

267 ^oC

Vinblastin H₂O Solubility

Negligible

Vinblastin State

Solid

Vinblastin LogP

5.587

Vinblastin Dosage Forms

Liquid; Powder for solution; Solution

Vinblastin Indication

For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Vinblastin Pharmacology

Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Vinblastin Absorption